Design a Cellular Environment Model to Predict Radiation Damage of Lung Cells Induced Radon Progeny Alpha Particles

Alpha particle irradiation from radon progeny is one of the major natural source of effective dose for public population. Oncogenic transformation is a biological effectivness of radon progeny alpha particle hits. Various biological models including cultured cells and animals have been found useful for studing the carcinogenesis effects of radon progeny alpha particles. In this paper, sugarscape cellular automata has been presented for computational study of complex biological effect of radon progeny alpha particles in lung bronchial airways. The model included mechanism of DNA damage induced alpha particles hits and formation of transformation in the lung cells. The metabolism rate of infected cell induced alpha particles traversals in sugarscape cellular automata was followed to reach oncogenic transformation. The model results were successfully validated by comparison with in vitro oncogenic transformation data for C3H 10T1/2 cells. This model provides an opportunity to study the cellular and molecular changes at the various stages in radiation carcinogenesis involving human cells. It has become well known that simulation can be used to investigate complex biomedical systems in situations where traditional methodologies are difficult or too costly to employ.